Publications

 

 

  1. Y. Altay, M. Tezcan, S. Otto
    Emergence of a New Self-Replicator from a Dynamic Combinatorial Library Requires a Specific Pre-Existing Replicator
    J. Am. Chem. Soc. 2017, doi:10.1021/jacs.7b07346.


  2. I. Cvrtila, H. Fanlo-Virgós, Gaël Schaeffer, G. M. Santiago, S. Otto
    Redox Control over Acyl Hydrazone Photoswitches
    J. Am. Chem. Soc. 2017, 139, 12459-12465. doi:10.1021/jacs.7b03724.


  3. D. Komáromy, M. Tezcan, G. Schaeffer, I. Marić, S. Otto
    Effector-Triggered Self-Replication in Coupled Subsystems
    Angew. Chem. 2017, doi:10.1002/ange.201707191.


  4. J. H. van Esch, R. Klaijn, S. Otto
    Chemical systems out of equilibrium
    Chem. Soc. Rev. 2017, 46, 5474-5475. doi:10.1039/c7cs90088k.


  5. P. W. J. M. Frederix, J. Idé, Y. Altay, G. Schaeffer, M. Surin, D. Beljonne, A. S. Bondarenko, T. L. C. Jansen, S. Otto, S. J. Marrink
    Structural and Spectroscopic Properties of Assemblies of Self-Replicating Peptide Macrocycles
    ACS Nano. 2017, 11, 7858-7868. doi:10.1021/acsnano.7b02211.


  6. H. Duim, S. Otto
    Towards open-ended evolution in self-replicating molecular systems
    Beilstein J. Org. Chem. 2017, 13, 1189-1203. doi:10.3762/bjoc.13.118.


  7. B. M. Matysiak, P. Nowak, I. Cvrtila, C. G. Pappas, B. Liu, D. Komáromy, S. Otto
    Antiparallel Dynamic Covalent Chemistries
    J. Am. Chem. Soc. 2017, 139, 6744-6751. doi:10.1021/jacs.7b02575.


  8. G. Ashkenasy, T. M. Hermans, S. Otto, A. F. Taylor
    Systems chemistry
    Chem. Soc. Rev. 2017, 46, 2543-2554. doi:10.1039/C7CS00117G.


  9. D. Komáromy, M. C. A. Stuart, G. M. Santiago, M. Tezcan, V. V. Krasnikov, S. Otto
    Self-Assembly Can Direct Dynamic Covalent Bond Formation toward Diversity or Specificity
    J. Am. Chem. Soc. 2017, 139, 6234-6241. doi:10.1021/jacs.7b01814.


  10. E. Mattia, A. Pal, G. Leonetti, S. Otto.
    Mechanism of Building Block Exchange in Stacks of Self-Replicating Macrocycles
    Synlett 2017, 28, 103-107. doi:10.1055/s-0036-1589709.


  11. M. Mondal, N. Radeva, H. Fanlo-Virgós, S. Otto, G. Klebe, A.K.H. Hirsch
    Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin: Fragment-Based Drug Design Facilitated by Dynamic Combinatorial Chemistry
    Angew. Chem. Int. Ed. 2016, 55, 9422-9426. doi:10.1002/ange.201603074.


  12. J. W. Sadownik, E. Mattia, P. Nowak, S. Otto.
    Diversification of self-replicating molecules.
    Nature Chem. 2016, 8, 264-269. doi:10.1038/nchem.2419.


  13. V. D. Nguyen, A. Pal, F. Snijkers, M. Colomb-Delsuc, G. Leonetti, S. Otto, J. van der Gucht.
    Multi-step control over self-assembled hydrogels of peptide-derived building blocks and a polymeric cross-linker.
    Soft Matter 2016, 12, 432-440. doi:10.1039/C5SM02088C.


  14. Y. Han, P. Nowak, M. Colomb-Delsuc, M. Pernia Leal, S. Otto.
    Instructable Nanoparticles Using Dynamic Combinatorial Chemistry.
    Langmuir 2015, 31, 12658–12663. doi:10.1021/acs.langmuir.5b03673.


  15. P. Nowak, M. Colomb-Delsuc, S. Otto, J. Li.
    Template-Triggered Emergence of a Self-Replicator from a Dynamic Combinatorial Library.
    J. Am. Chem. Soc. 2015, 137, 10965–10969. doi:10.1021/jacs.5b04380.


  16. M. Colomb-Delsuc, E. Mattia, J. W. Sadownik, S. Otto.
    Exponential self-replication enabled through a fibre elongation/breakage mechanism.
    Nat. Commun. 2015, 6, 7427. doi:10.1038/ncomms8427.


  17. A. Pal, M. Malakoutikhah, G. Leonetti, M. Tezcan, M. Colomb-Delsuc, V. D. Nguyen, J. van der Gucht, S. Otto.
    Controlling the Structure and Length of Self-Synthesizing Supramolecular Polymers through Nucleated Growth and Disassembly.
    Angew. Chem. Int. Ed. 2015, 54, 7852–7856. doi: 10.1002/anie.201501965.


  18. P. Nowak, V. Saggiomo, F. Salehian, M. Colomb-Delsuc, Y. Han, S. Otto
    Localized Template-Driven Functionalization of Nanoparticles by Dynamic Combinatorial Chemistry
    Angew. Chem. Int. Ed. 2015, 54, 4192–4197. doi: 10.1002/anie.201409667.


  19. E. Mattia, S. Otto
    Supramolecular systems chemistry
    Nat. Nanotechnol. 2015, 10, 111–119. doi: 10.1038/nnano.2014.337.


  20. G. Leonetti, S. Otto
    Solvent Composition Dictates Emergence in Dynamic Molecular Networks Containing Competing Replicators
    J. Am. Chem. Soc. 2015, 137, 2067–2072. doi: 10.1021/ja512644f.


  21. J. Li, P. Nowak, S. Otto
    An Allosteric Receptor by Simultaneous “Casting” and “Molding” in a Dynamic Combinatorial Library
    Angew. Chem. Int. Ed. 2015, 54, 833-837. doi: 10.1002/anie.201408907.


  22. J. Li, I. Cvrtila, M. Colomb-Delsuc, E. Otten, S. Otto
    An “Ingredients” Approach to Functional Self-Synthesizing Materials: A Metal-Ion-Selective, Multi-Responsive, Self-Assembled Hydrogel
    Chem. Eur. J. 2014, 20, 15709 – 15714. doi: 10.1002/chem.201404977.


  23. B.Grzybowski, S. Otto and D. Philp
    Systems chemistry: a web themed issue
    Chem. Commun., 2014, 50, 14924-14925. doi: 10.1039/C4CC90422B.


  24. H. Fanlo-Virgós, A.N.R. Alba, S. Hamieh, M. Colomb-Delsuc,S. Otto
    Transient Substrate-Induced Catalyst Formation in a Dynamic Molecular Network
    Angew. Chem. Int. Ed.  2014, 53, 11346–11350. doi: 10.1002/anie.201403480.


  25. J. Li, P. Nowak, H. Fanlo-Virgos, S. Otto
    Catenanes from Catenanes: Quantitative Assessment of Cooperativity in Dynamic Combinatorial Catenation
    Chem. Sci.  2014, 5, 4968-4974. doi: 10.1039/C4SC01998A.


  26. M. Malakoutikhah, J.J-P. Peyralans, M. Colomb-Delsuc, h. Fanlo-Virgos, M. C. A. Stuart, S. Otto
    Uncovering the Selection Criteria for the Emergence of Multi-Building-Block Replicators from Dynamic Combinatorial Libraries.
    J. Am. Chem. Soc. 2013, 135, 49, 18406-18417. doi: 10.1021/ja4067805.


  27. S. Hamieh, V. Saggiomo, P. Nowak, E. Mattia, R. F. Ludlow, S. Otto
    A "Dial-A-Receptor" Dynamic Combinatorial Library
    Angew. Chem. Int. Ed.2013, 52, 47, 12368-12372. doi: 10.1002/anie.201305744.


  28. J. Li, P. Nowak, S. Otto
    Dynamic Combinatorial Libraries: From Exploring Molecular Recognition to Systems Chemistry.
    J. Am. Chem. Soc. 2013, 135, 25, 9222-9239. doi: 10.1021/ja402586c.


  29. S. Otto
    The role of solvent cohesion in nonpolar solvation.
    Chem. Sci. 2013, 4, 2953-2959. doi: 10.1039/C3SC50740H.


  30. W. H. Rombouts, M. Colomb-Delsuc, M. W. T. Werten, S. Otto, F. A. de Wolf, J. van der Gucht
    Enhanced rigidity and rupture strength of composite hydrogel networks of bio-inspired block copolymers.
    Soft Matter 2013, 9, 6936-6942. doi: 10.1039/C3SM00091E.


  31. V. Saggiomo, Y. R. Hristova, R. F. Ludlow, S. Otto
    Systems chemistry: using thermodynamically controlled networks to assess molecular similarity.
    J. Syst. Chem. 2013, 4:2. doi: 10.1186/1759-2208-4-2.


  32. S. Hamieh, R. F. Ludlow, O. Perraud, K. R. West, E. Mattia, S. Otto
    A Synthetic Receptor for Nicotine from a Dynamic Combinatorial Library.
    Org. Lett. 2012, 14, 21, 5404-5407. doi: 10.1021/ol302260n.


  33. J. Wang, M. A. Cohen Stuart, A. T. M. Marcelis, M. Colomb-Delsuc, S. Otto, J. van der Gucht
    Stable Polymer Micelles Formed by Metal Coordination.
    Macromolecules 2012, 45, 17, 7179-7185. doi: 10.1021/ma301323z.


  34. S. Otto, J. B. F. N. Engberts
    Structure and properties of water.
    In "Water in Organic Synthesis". Science of Synthesis, Thieme, Stuttgart 2012, p17-51.


  35. V. Saggiomo, S. Otto, I. Marques, V. Félix, T. Torroba, R. Quesada
    The role of lipophilicity in transmembrane anion transport.
    Chem. Comm. 2012, 48, 5274-5276. doi: 10.1039/C2CC31825C.


  36. S. Otto
    Dynamic Molecular Networks: From Synthetic Receptors to Self-Replicators.
    Acc. Chem. Res. 2012doi: 10.1021/ar200246j .


  37. Z. Rodriguez-Docampo, E. Eugenieva-Ilieva, C. Reyheller, A. M. Belenguer, S. Kubik, S. Otto
    Dynamic combinatorial development of a neutral synthetic receptor that binds sulfate with nanomolar affinity in aqueous solution.
    Chem. Comm. 201147, 9798-9800. doi: 10.1039/C1CC13451E.


  38. J. Li, J. M. A. Carnall, M. C. A. Stuart, S. Otto
    Hydrogel formation upon photoinduced covalent capture of macrocycle stacks from dynamic combinatorial libraries.
    Angew. Chem., Int. Ed. 201150, 8384–8386. doi: 10.1002/anie.201103297.


  39. R. A. R. Hunt, S. Otto
    Dynamic combinatorial libraries: new opportunities in systems chemistry.
    Chem. Comm. 201147, 847-858. doi: 10.1039/C0CC03759A.


  40. H. Y. Au-Yeung, F. B. L. Cougnon, G. Dan Pantoş, S. Otto, J. K. M. Sanders
    Exploiting donor–acceptor interactions in aqueous dynamic combinatorial libraries: exploratory studies of simple systems.
    Chem. Sci. 20101, 567-574. doi: 10.1039/C0SC00307G.


  41. F. M. Mansfeld, H. Y. Au-Yeung, J. K. M. Sanders, S. Otto
    Dynamic combinatorial chemistry at the phospholipid bilayer interface.
    J. Syst. Chem. 20101doi: 10.1186/1759-2208-1-12.


  42. G. von Kiedrowski, S. Otto, P. Herdewijn
    Welcome home, systems chemists!
    J. Syst. Chem. 20101doi: 10.1186/1759-2208-1-1.


  43. R. F. Ludlow, S. Otto
    The impact of the size of dynamic combinatorial libraries on the detectability of molecular recognition induced amplification.
    J. Am. Chem. Soc. 2010132, 5984–5986. doi: 10.1021/ja1013689.


  44. P. Besenius, P. A. G. Cormack, R. F Ludlow, S. Otto, D. C. Sherrington
    Affinity chromatography in dynamic combinatorial libraries: one-pot amplification and isolation of a strongly binding receptor.
    Org. Biomol. Chem. 20108, 2414-2418. doi: 10.1039/C000333F.


  45. J. M. A. Carnall, C. A. Waudby, A. M. Belenguer, M. C. A. Stuart, J. J.-P. Peyralans, S. Otto
    Mechanosensitive self-replication driven by self-organization.
    Science 2010327, 1502-1506. doi: 10.1126/science.1182767.


  46. J. H. R. Reek, S. Otto (Editors)
    Dynamic Combinatorial Chemistry
    Wiley-VCH, Weinheim, 2010. More information.


  47. S. Otto
    Molecular machines: Tiny steps (invited highlight).
    Nature Chem. 20102, 75-76. doi: 10.1038/nchem.525.


  48. R. A. R. Hunt, R. F. Ludlow, S. Otto
    Estimating equilibrium constants for aggregation from the product distribution of a dynamic combinatorial library.
    Org. Lett. 200911, 5110-5113. doi: 10.1021/ol901656x.


  49. F. M. Mansfeld, G. Feng, S. Otto
    Photo-induced molecular-recognition-mediated adhesion of giant vesicles.
    Org. Biomol. Chem. 20097, 4289–4295. doi: 10.1039/B910197G.


  50. J. J.-P. Peyralans, S. Otto
    Recent highlights in systems chemistry.
    Curr. Opin. Chem. Biol. 200913, 705–713. doi: 10.1016/j.cbpa.2009.08.006.


  51. S. Otto
    Molecular self-assembly: Helping themselves.
    Nature Nanotechn. 20094, 13. doi: 10.1038/nnano.2008.387.


  52. A. Likhitsup, R. J. Deeth, S. Otto, A. Marsh
    Apparent non-statistical binding in a ditopic receptor for guanosine.
    Org. Biomol. Chem. 20097, 2093–2103. doi: 10.1039/B812969J.


  53. H. Y. Au–Yeung, P. Pengo, G. D. Pantos, S. Otto, J. K. M. Sanders
    Templated amplification of a naphthalenediimide-based receptor from a donor-acceptor dynamic combinatorial library in water.
    Chem. Commun. 2009, 419-421. doi: 10.1039/B816979A.


  54. R. F. Ludlow, S. Otto
    Two vial, LC-MS identification of ephedrine receptors from a dynamic combinatorial library of over 10,000 components.
    J. Am. Chem. Soc. 2008130, 12218-12219. doi: 10.1021/ja803317k.


  55. K. R. West, R. F. Ludlow, P. T. Corbett, P. Besenius, F. M. Mansfeld, P. A. G. Cormack, D. C. Sherrington, J. M. Goodman, M. C. A. Stuart, S. Otto
    Dynamic combinatorial discovery of a [2]-catenane and its template-induced conversion into a molecular square synthetic receptor.
    J. Am. Chem. Soc. 2008130, 10834-10835. doi: 10.1021/ja801508q.


  56. Z. Rodriguez-Docampo, S. Otto
    Orthogonal or simultaneous use of disulfide chemistry and hydrazone exchange in dynamic covalent chemistry.
    Chem. Commun. 2008, 5301-5303. doi: 10.1039/B808725C.


  57. P. Besenius, P. A. G. Cormack, J. Liu, S. Otto, J. K. M. Sanders, D. C. Sherrington
    Tailored polymer-supported templates in dynamic combinatorial libraries: simultaneous selection, amplification and isolation of synthetic receptors.
    Chem. -Eur. J. 200814, 9006–9019. doi: 10.1002/chem.200800326.


  58. P. Besenius, P. A. G. Cormack, R. F Ludlow, S. Otto, D. C. Sherrington
    Polymer-supported cationic templates for molecular recognition of anionic hosts in water.
    Chem. Commun. 2008, 2809–2811. doi: 10.1039/B802982B.


  59. P. T. Corbett, J. K. M. Sanders, S. Otto
    Exploring the relation between amplfication and binding in dynamic combinatorial libraries of macrocyclic synthetic receptors in water.
    Chem. Eur. J. 2008, 2153-2166. doi: 10.1002/chem.200701413.


  60. R. F. Ludlow, S. Otto
    Systems chemistry.
    Chem. Soc. Rev. 200837, 101-108. doi: 10.1039/B611921M.
    Highlighted in Chemical Science 2008, 5(1), C5.


  61. R. F. Ludlow, J. Liu, H. Li, S. L. Roberts, J. K. M. Sanders, S. Otto
    Host-guest binding constants can be estimated directly from the product distributions of dynamic combinatorial libraries.
    Angew. Chem., Int. Ed. 2007, 46, 5762-5764. doi: 10.1002/anie.200700292.


  62. S. Otto, K. Severin
    Dynamic combinatorial libraries for the development of synthetic receptors and sensors.
    Topics Curr. Chem. 2007, 277, 267-288. doi: 10.1007/128_2007_116.


  63. R. J. Sarma, S. Otto, J. R. Nitschke
    Disulfides, imines and metal coordination within a single system: interplay between three dynamic equilibria.
    Chem. -Eur. J. 2007, 13, 9542-9546. doi: 10.1002/chem.200701228.


  64. P. T. Corbett, J. K. M. Sanders, S. Otto
    Systems chemistry: pattern formation in random dynamic combinatorial libraries.
    Angew. Chem., Int. Ed. 2007, 46, 8858-8861. doi: 10.1002/ange.200702460.


  65. Z. Rodriguez-Docampo, S. I. Pascu, S. Kubik, S. Otto
    Noncovalent interactions within a synthetic receptor can reinforce guest binding.
    J. Am. Chem. Soc. 2006128, 11206-11210. doi: 10.1021/ja062389h.


  66. P. T. Corbett, J. Leclaire, L. Vial, K. R. West, J.-L. Wietor, J. K. M. Sanders, S. Otto
    Dynamic combinatorial chemistry.
    Chem. Rev. 2006106, 3652-3711. doi: 10.1021/cr020452p.


  67. L. Vial, R. F. Ludlow, J. Leclaire, S. Otto
    Controlling the biological effects of spermine using a synthetic receptor.
    J. Am. Chem. Soc. 2006128, 10253-10257. doi: 10.1021/ja062536b.


  68. P. Pengo, G. D. Pantos, S. Otto, J. K. M. Sanders
    Efficient and mild microwave-assisted stepwise functionalization of naphthalenediimide with alpha amino acids.
    J. Org. Chem. 200671, 7063-7066. doi: 10.1021/jo061195h.


  69. A. Kraft, A. Tominey, D. Andrew, J. Dupré, A. McIver, L. Oliphant, G. M. Rosair, S. Otto
    Supramolecular binding of protonated amines to functionalized microgel particles.
    Polym. Preprints 200647, 937-938.


  70. C. Suksai, S. Figueiras Gómez, A. Chhabra, J. Liu, J. N. Skepper, T. Tuntulani, S. Otto
    Controlling the morphology of aggregates of an amphiphilic synthetic receptor through host-guest interactions.
    Langmuir 200622, 5994-5997. doi: 10.1021/la0609470.


  71. S. Otto
    Reinforced molecular recognition as an alternative to rigid receptors.
    Dalton Trans. 2006, 2861-2864. doi: 10.1039/B515817F.


  72. P. T. Corbett, J. K. M. Sanders, S. Otto
    Competition between receptors in dynamic combinatorial libraries: amplification of the fittest?
    J. Am. Chem. Soc. 2005127, 9390-9392. doi: 10.1021/ja0509026.


  73. S. Otto
    Exploring and exploiting molecular recognition using covalent chemistry under thermodynamic control.
    J. Mat. Chem. 200515, 3357-3361. doi: 10.1039/b500703h.


  74. L. Vial, J. K. M. Sanders, S. Otto
    A catalyst for an acetal hydrolysis reaction from a dynamic combinatorial library.
    New J. Chem. 200529, 1001-1003. doi: 10.1039/B505316A.


  75. K. West, S. Otto
    Reversible covalent chemistry in drug delivery.
    Curr. Drug Disc. Techn. 20052, 123-160. doi: 10.2174/1570163054866882.


  76. P. T. Corbett, L. H. Tong, J. K. M. Sanders, S. Otto
    Diastereoselective amplification of an induced-fit receptor from a dynamic combinatorial library.
    J. Am. Chem. Soc. 2005127, 8902-8903. doi: 10.1021/ja050790i.


  77. K. West, K. Bake, S. Otto
    Dynamic combinatorial libraries of disulfide cages in water.
    Org. Lett. 2005, 2615-2618. doi: 10.1021/ol0507524.


  78. Leclaire, L. Vial, S. Otto, J. K. M. Sanders
    Expanding diversity in dynamic combinatorial libraries: simultaneous exchange of disulfide and thioester linkages.
    Chem. Commun. 2005, 1959-1961. doi: 10.1039/B500638D.


  79. T. S. R. Lam, A. Belenguer, S. L. Roberts, C. Naumann, T. Jarrosson, S. Otto, J. K. M. Sanders
    Amplification of acetylcholine-binding catenanes from dynamic combinatorial libraries.
    Science 2005308, 667-669. doi: 10.1126/stke.2822005tw168.


  80. S. Kubik, R. Goddard, S. Otto, S. Pohl, C. Reyheller, S. Stüwe
    Optimization of the binding properties of a synthetic anion receptor using rational and combinatorial strategies.
    Biosensors Bioelectronics 200520, 2364-2375. doi: 10.1016/j.bios.2004.01.035.


  81. S. I. Pascu, T. Jarrosson, C. Naumann, S. Otto, G. Kaiser, J. K. M. Sanders
    Cation-reinforced donor-acceptor pseudorotaxanes.
    New J. Chem. 200529, 80-89. doi: 10.1039/B415418E.


  82. P. T. Corbett, S. Otto, J. K. M. Sanders
    What are the limits to the size of effective dynamic combinatorial libraries?
    Org. Lett. 20046, 1825-1827. doi: 10.1021/ol049398k.


  83. P. T. Corbett, S. Otto, J. K. M. Sanders
    Correlation between host-guest binding and host amplification in simulated dynamic combinatorial libraries.
    Chem. Eur. J. 200410, 3139-3143. doi: 10.1002/chem.200400300.


  84. S. Otto, J. K. M. Sanders
    Supramolecular Libraries.
    Encyclopedia of Supramolecular Chemistry, J. Atwood, J. Steed (Eds.) Marcel Dekker, New York, 2004, 1427-1433.


  85. G. Kaiser, T. Jarrosson, S. Otto, Y.-F. Ng, A. D. Bond, J. K. M. Sanders
    Lithium-templated synthesis of a donor-acceptor pseudorotaxane and catenane.
    Angew. Chem. Int. Ed. 200443, 1959-1962. doi: 10.1002/ange.200353075.


  86. S. Otto, J. B. F. N. Engberts
    Hydrophobic interactions and chemical reactivity.
    Org. Biomol. Chem. 20031, 2809-2820. doi: 10.1039/B305672D.


  87. S. Otto, S. Kubik
    Dynamic combinatorial optimization of a neutral receptor that binds inorganic anions in aqueous solution.
    J. Am. Chem. Soc. 2003125, 7804-7805. doi: 10.1021/ja0351589.


  88. S. L. Roberts, R. L. E. Furlan, S. Otto, J. K. M. Sanders
    Metal-ion induced amplification of three receptors from dynamic combinatorial libraries of peptide-hydrazones.
    Org. Biomol. Chem. 20031, 1625-1633. doi: 10.1039/B300956D.


  89. E. Stulz, S. M. Scott, A. D. Bond, S. Otto, J. K. M. Sanders
    Complexation of diphenyl(phenylacetenyl)phosphine to rhodium(III) tetraphenyl porphyrins: synthesis, structural, spectroscopic and thermodynamic studies.
    Inorg. Chem. 200342, 3086-3096. doi: 10.1021/ic026257a.


  90. S. Otto
    Dynamic combinatorial chemistry: a new method for the selection and preparation of synthetic receptors.
    Curr. Opin. Drug Discovery Development 20036, 509-520.


  91. B. Brisig, J. K. M. Sanders, S. Otto
    Selection and amplification of a catalyst from a dynamic combinatorial library.
    Angew. Chem. Int. Ed. 200342, 1270-1273. doi: 10.1002/anie.200390326.
    Highlighted in C&E News, May 12, 2003, 36.


  92. S. Otto, R. L. E. Furlan, J. K. M. Sanders
    Selection and amplification of hosts from dynamic combinatorial libraries of macrocyclic disulfides.
    Science 2002297, 590-593. doi: 10.1126/science.1072361.
    Highlighted in C&E News, Sept 2, 2002, 31-33 and included among the Chemistry Highlights of 2002 in C&E News, Dec 16, 2002, 38.


  93. S. Otto, R. L. E. Furlan, J. K. M. Sanders
    Recent developments in dynamic combinatorial chemistry.
    Curr. Opin. Chem. Biol. 20026, 321-327. doi: 10.1016/S1367-5931(02)00331-9.


  94. R. L. E. Furlan, S. Otto, J. K. M. Sanders
    Supramolecular templating in thermodynamically controlled synthesis.
    Proc. Natl. Acad. Sci., U.S.A. 200299, 4801-4804. doi: 10.1073/pnas.022643699.


  95. S. Otto, R. L. E. Furlan, J. K. M. Sanders
    Dynamic Combinatorial Chemistry.
    Drug Discovery Today 20027, 117-125. doi: 10.1016/S1359-6446(01)02086-4.


  96. R. L. E. Furlan, Y.-F. Ng, S. Otto, J. K. M. Sanders
    A new cyclic pseudo-peptide receptor for Li+ from a dynamic combinatorial library.
    J. Am. Chem. Soc. 2001123, 8876-8877. doi: 10.1021/ja0160703.


  97. S. Otto, J. B. F. N. Engberts
    Diels-Alder reactions in micellar media.
    Reactions and Synthesis in Surfactant Systems, Ed: Texter, J. Marcel Dekker, New York, 2001, 247-263.


  98. S. Otto, R. L. E. Furlan, J. K. M. Sanders
    Dynamic combinatorial libraries of macrocyclic disulfides in water.
    J. Am. Chem. Soc. 2000122, 12063-12064. doi: 10.1021/ja005507o.
    Highlighted in Science 2000, 290, 1857.


  99. A. F. DiGiorgio, S. Otto, P. Bandyopadhyay, S. L. Regen
    Ion conductors that favor passive transport in ergosterol-rich over cholesterol-rich phospholipid membranes.
    J. Am. Chem. Soc. 2000122, 11029-11030. doi: 10.1021/ja002039+.


  100. S. Otto, V. Janout, A. F. DiGiorgio, M. C. Young, S. L. Regen
    Detection of nonideal mixing of phospholipids in fluid bilayers.
    J. Am. Chem. Soc. 2000122, 1200-1204. doi: 10.1021/ja993585+.


  101. S. Otto, J. B. F. N. Engberts
    Diels-Alder reactions in water.
    Pure Appl. Chem. 200072, 1365-1372. doi: 10.1351/pac200072071365.


  102. S. Otto, M. Osifchin, S. L. Regen
    Squeezing a synthetic ionophore and mechanistic insight out of a lipid bilayer.
    J. Am. Chem. Soc. 1999121, 10440-10441. doi: 10.1021/ja992920r.


  103. S. Otto, M. Osifchin, S. L. Regen
    Modular control over the selectivity of self-assembling and membrane-spanning ion conductors.
    J. Am Chem. Soc. 1999121, 7276-7277. doi: 10.1021/ja990505t.


  104. S. Otto, J. B. F. N. Engberts
    A systematic study of ligand effects on a lewis-acid-catalyzed Diels-Alder reaction in water. Water-enhanced enantioselectivity.
    J. Am. Chem. Soc. 1999121, 6798-6806. doi: 10.1021/ja984273u.


  105. A. Meijer, S. Otto, J. B. F. N. Engberts
    Effects of the hydrophobicity of the reactants on Diels-Alder reactions in water.
    J. Org. Chem. 199863, 8989-8994. doi: 10.1021/jo981359x.


  106. S. Otto, J. B. F. N. Engberts, J. C. T. Kwak
    Million-fold acceleration of a Diels-Alder reaction due to combined Lewis-acid and micellar catalysis in water.
    J. Am. Chem. Soc. 1998120, 9517-9525. doi: 10.1021/ja9816537.


  107. S. Otto, G. Boccaletti, J. B. F. N. Engberts
    A chiral Lewis-acid catalyzed Diels-Alder reaction. Water-enhanced enantioselectivity.
    J. Am. Chem. Soc. 1998120, 4238-4239. doi: 10.1021/ja972772+.
    Highlighted in Chemie Unserer Zeit 1998, 32, 220.


  108. J. B. F. N. Engberts, B. L. Feringa, E. Keller, S. Otto
    Lewis-acid catalysis of carbon-carbon bond forming reactions in water.
    Recl. Trav. Chim. Pays-Bas, 1996115, 457. doi: 10.1002/recl.19961151103.


  109. S. Otto, F. Bertoncin, J. B. F. N. Engberts
    Lewis-acid catalysis of a Diels-Alder reaction in water.
    J. Am. Chem. Soc. 1996118, 7702-7707. doi. 10.1021/ja960318k.


  110. S. Otto, J. B. F. N. Engberts
    Lewis-acid catalysis of a Diels-Alder reaction in water.
    Tetrahedron Lett. 199536, 2645-2648. doi: 10.1016/0040-4039(95)00304-U.


  111. S. Otto, W. Blokzijl, J. B. F. N. Engberts
    Diels-Alder reactions in water. Effects of hydrophobicity and hydrogen bonding.
    J. Org. Chem. 199459, 5372-5376. doi: 10.1021/jo00097a045.